Abstract
Magnetic sensors present a transformative solution for non-invasive biomedical monitoring by overcoming critical limitations associated with conventional sensing technologies, such as optical sensors, whose performance degrades due to sensor-skin coupling effects. We systematically examine the sensor-skin coupling effect, emphasizing its impact on diagnostic accuracy. Our analysis reveals the complex challenges associated with sensor-skin interfaces, including biomechanical, pigmentary, and textural variations that affect sensor performance. We introduce a novel methodology that combines advanced biomaterial development, adaptive calibration techniques, and sophisticated signal processing algorithms. Our findings highlight that skin-specific characteristics contribute to measurement uncertainties in existing sensing technologies, indicating an urgent need for adaptive interface solutions. We propose a conceptual model for developing biocompatible sensor interfaces that maintain measurement integrity across varied physiological conditions, drawing insights from materials science, bioengineering, and clinical research. This review provides a comprehensive examination of sensor-skin interactions and outlines a roadmap for next-generation health monitoring technologies, along with strategic recommendations for enhancing the reliability of non-invasive diagnostics through innovative biomaterial solutions.