Abstract
BACKGROUND: Although many studies have shown that fine particulate matter (PM(2.5)) is associated with respiratory diseases (RDs) in children, fewer studies have examined this association in developing countries. We aimed to use the latest PM(2.5) standards to investigate the interaction between PM(2.5) and RDs among children in Guangzhou. METHODS: We included 18,291 pediatric inpatients aged 0-14 years with a primary diagnosis of RDs admitted to hospitals in Guangzhou, China, from January 1, 2018, to December 31, 2021. The association between PM(2.5) and RDs was analysed using a non-linear distributed lag model, and additional subgroup analyses were performed based on sex and season. RESULTS: The association of PM(2.5) with RDs showed a zigzag shape. Specifically, the cumulative effects of PM(2.5) at the 25th, 50th, and 75th percentiles, with a lag of 0-14 days, were associated with increases in the relative risk (RR) of RDs by 0.4% (95% confidence interval (CI) [1.000-1.007]), 3.4% (95% CI [1.004-1.065]), and 7.7% (95% CI [1.010-1.149]), respectively. Additionally, for each 10 µg/m(3) increase in PM(2.5) concentration, the on-the-day lagged effect on lag day 4 and lag day 7 was associated with an elevated risk of RDs, with RR of 1.018 (95% CI [1.002-1.034]) and 1.016 (95% CI [1.000-1.032]), respectively. Additionally, PM(2.5) exposure significantly increased the risk of RDs in boys and elevated that risk in children during both summer and winter seasons. CONCLUSIONS: This study reveals a significant effect of PM(2.5) exposure on RDs in children, with notably elevated risks during summer and winter seasons. These findings underscore the critical importance of implementing air quality improvement measures to safeguard children's health, particularly in developing countries.