Abstract
OBJECTIVE: Inhalation therapy is recommended by the World Health Organization as the first-line treatment for chronic obstructive pulmonary disease (COPD) due to its rapid onset of action, good safety profile, ease of use, and portability. High medication adherence in COPD patients is crucial for enhancing disease management. The aim of this study was to assess the level of disease control, adherence to inhaled medication therapy, and potential factors influencing treatment adherence among COPD patients. METHODS: A paper-based questionnaire was used to survey COPD patients who were outpatients or inpatients at the First Affiliated Hospital of Harbin Medical University between January 2019 and October 2023. Patients were included if they had been diagnosed with stable COPD for more than 12 months, were prescribed inhaled medications for post-consultation or post-discharge management, and had used these medications for at least 8 weeks with follow-up review. Questionnaires were administered at the time of consultation and at the 8-week follow-up to comprehensively evaluate patients' adherence to inhaled medications based on their medication administration methods, frequency, and other relevant factors. Categorical data were described using frequencies and percentages, and comparisons between groups were conducted using the chi-square test. For the analysis of risk factors, binary logistic regression analysis was employed. To avoid collinearity among variables, a stepwise regression method was utilized for variable selection. A P-value < 0.05 was considered statistically significant. RESULTS: A total of 977 patients were included, with an average age of 63 ± 9 years. Among them, 40.9% of the patients demonstrated high adherence to inhaled medication therapy. Patients who were under 70 years old (P = 0.03), had a higher annual household income (P = 0.04), had family supervision (P = 0.01), and had medical insurance (P = 0.02) exhibited higher adherence to inhaled medication therapy. CONCLUSION: Among the surveyed patients, those who were under 70 years old (OR = 5.1, CI = 1.13-23.11) and had family supervision (OR = 3.26, CI = 1.3-8.21) demonstrated better medication adherence. This suggests that physicians could potentially improve patient medication adherence, optimize disease control, and enhance the overall quality of life for these patients by considering targeted interventions, such as identifying and educating elderly patients, intensifying tailored promotional activities, and encouraging family members to supervise medication use.