Abstract
Lymphoma originates from the lymphatic hematopoietic system and is prone to develop second tumors. We reported a case of lymphoma initially manifesting systematic lymphadenopathies and lung space-occupying lymphoma that developed to lung squamous cell carcinoma in 30 months. The diseases once responded satisfactorily to chemotherapy combined with immunotherapy but progressed after 8 months. Following afatinib administration achieved sustained remission and the progression-free survival is 11 months. Rarely does lymphoma combine with lung cancer and more rarely does lung cancer develop in the original focus of pulmonary lymphoma; first-line and secondary treatment remained potent in treating the complexity.