Abstract
BACKGROUND AND OBJECTIVE: Postoperative pulmonary rehabilitation in non-small cell lung cancer (NSCLC) patients following thoracic surgery can be an important strategy for restoring functional exercise capacity. This study aimed to evaluate the changes in the Glittre-ADL test (TGlittre) in patients with NSCLC undergoing thoracic surgery and early home-based pulmonary rehabilitation and, subsequently, to assess the associations of the test results with muscle strength and quality of life (QoL). METHODS: This observational study evaluated 18 patients with NSCLC before and after home-based pulmonary rehabilitation. Before thoracic surgery and 3 months after pulmonary rehabilitation, the participants underwent the following assessments: St. George's Respiratory Questionnaire (SGRQ), spirometry, measurement of the diffusion capacity of the lung for carbon monoxide (DLCO), respiratory muscle strength, handgrip strength (HGS), quadriceps muscle strength, and TGlittre. RESULTS: When comparing the preoperative and postpulmonary rehabilitation periods, there was a significant increase in HGS [21.6 (19-29) vs. 28.5 (26-33) kgf, p = 0.011] with preservation of TGlittre time [3.6 (3.2-4) vs. 3.6 (3-4.1) min, p = 0.87]. In addition, there was a significant decrease in lung function and SGRQ scores. Preoperative TGlittre time significantly correlated with maximum inspiratory pressure (MIP, r (s) = -0.491, p = 0.038) and DLCO (r (s) = -0.621, p = 0.006). TGlittre time measured in postpulmonary rehabilitation was significantly correlated with HGS (r (s) = -0.664, p = 0.002) and the MIP (r (s) = -0.478, p = 0.045). CONCLUSION: In patients with NSCLC undergoing thoracic surgery and pulmonary rehabilitation, there was an increase in muscle strength and preservation of functional exercise capacity, although there was a decrease in lung function and QoL. There were interrelations of TGlittre time with MIP and pulmonary diffusion in the preoperative period and of TGlittre time with HGS and MIP following the home-based pulmonary rehabilitation. Although the results are promising, additional studies with a larger number of patients and a control group are needed to further support these findings.