Abstract
BACKGROUND: Severe coronavirus disease 2019 (COVID-19) may require veno-venous extracorporeal membrane oxygenation (V-V ECMO). While V-V ECMO is offered in severe lung injury to COVID-19, long-term respiratory follow-up in these patients is missing. Therefore, we aimed at providing comprehensive data on the long-term respiratory effects of COVID-19 requiring V-V ECMO support during the acute phase of infection. METHODS: In prospective observational cohort study design, patients with severe COVID-19 receiving invasive mechanical ventilation and V-V ECMO (COVID group, n = 9) and healthy matched controls (n = 9) were evaluated 6 months after hospital discharge. Respiratory system resistance at 5 and 19 Hz (R(5), R(19)), and the area under the reactance curve (AX(5)) was evaluated using oscillometry characterizing total and central airway resistances, and tissue elasticity, respectively. R(5) and R(19) difference (R(5)-R(19)) reflecting small airway function was also calculated. Forced expired volume in seconds (FEV(1)), forced expiratory vital capacity (FVC), functional residual capacity (FRC), carbon monoxide diffusion capacity (DLCO) and transfer coefficient (KCO) were measured. RESULTS: The COVID group had a higher AX(5) and R(5)-R(19) than the healthy matched control group. However, there was no significant difference in terms of R(5) or R(19). The COVID group had a lower FEV(1) and FVC on spirometry than the healthy matched control group. Further, the COVID group had a lower FRC on plethysmography than the healthy matched control group. Meanwhile, the COVID group had a lower DLCO than healthy matched control group. Nevertheless, its KCO was within the normal range. CONCLUSION: Severe acute COVID-19 requiring V-V ECMO persistently impairs small airway function and reduces respiratory tissue elasticity, primarily attributed to lung restriction. These findings also suggest that even severe pulmonary pathologies of acute COVID-19 can manifest in a moderate but still persistent lung function impairment 6 months after hospital discharge. TRIAL REGISTRATION: NCT05812196.