Abstract
The dynamics of the COVID-19 pandemic have significantly changed since its initial outbreak. This study aimed to investigate the quality of life (QoL) of patients with cancer receiving chemotherapy in the specific context of Thailand during the COVID-19 pandemic. A cross-sectional study was conducted with 415 patients with cancer. Instruments used were a demographic and clinical characteristics form, the Edmonton Symptom Assessment Scale (cancer symptom burden), Strategies Used by People to Promote Health (self-care self-efficacy), and a Thai version of the Brief Form of the WHO Quality of Life Assessment. Data were analyzed using descriptive and inferential statistics. The participants had an average age of 56 years. They reported a moderate level of QoL across all domains and for the overall QoL during the pandemic. The results of the multiple linear regression model indicated that positive self-care self-efficacy, being married, having health insurance, stage of chemotherapy, and reduced cancer symptom burden were significant predictors of overall QoL (adjusted R(2) = 0.4940). Positive self-care self-efficacy also emerged as a primary predictor, positively influencing all QoL domains and overall QoL (p < 0.001). These findings emphasize the significance of self-care self-efficacy in enhancing the QoL of patients with cancer undergoing chemotherapy during the pandemic. Integrating interventions to bolster self-care self-efficacy into the care plans for these patients can help them manage their symptoms, cope with the side effects of cancer treatment, and enhance their overall well-being.