Abstract
Despite being the richest and most prepared nation in the world, the U.S. responded badly to the COVID-19 crisis. This paper examines the nature of political control and the essence of bureaucratic failure for the Centers for Disease Control and Prevention (CDC), an independent agency. In three case studies, we analyze the CDC's success in handling H1N1 and Ebola, and its failures on COVID-19. We find that the CDC suffered not only from political interference by the Trump Administration but also internal organizational problems that muted its ability to respond effectively. We conclude by offering policy prescriptions for addressing concerns of bureaucratic autonomy and success at the CDC.