Abstract
Interactions between species give rise to chemical pathways of communication that regulate the interactions of transboundary species. The communication between nematodes and other species primarily occurs through the regulation of chemicals, with key species including plants, insects, bacteria, and nematode-trapping fungi that are closely associated with nematodes. G protein-coupled receptors (GPCRs) play a crucial role in interspecies communication. Certain flp genes, which function as GPCRs, exert varying degrees of influence on how nematodes interact with other species. These receptors facilitate the transmission of corresponding signals, thereby completing the interactions between species. This paper introduces the interactions between nematodes and other species and discusses the role of GPCRs in these organisms, contributing to a deeper understanding of the impact and significance of GPCRs in cross-border regulation between nematodes and other species. Furthermore, it is essential to leverage GPCRs in efforts to control pests.