Abstract
BACKGROUND: In clinical practice, bilirubin levels are recognized as a crucial biochemical indicator closely associated with hepatobiliary function and the severity of biliary obstruction, and there is growing interest in exploring the potential correlation between varying preoperative bilirubin levels and clinical outcomes in patients with obstructive jaundice. Obstructive jaundice, characterized by impaired bile excretion and subsequent bilirubin accumulation, poses significant challenges to clinical treatment due to its heterogeneous etiologies and variable patient responses to intervention, highlighting the need for personalized therapeutic strategies based on key prognostic factors. This study conducted a single-center retrospective analysis to systematically investigate differences in patient clinical outcomes across different preoperative bilirubin levels. The aim of this study is to clarify the association between preoperative bilirubin stratification and postoperative recovery, complication rates, and long-term prognosis, thereby providing evidence-based support for establishing more rational, targeted, and individualized treatment strategies for patients with obstructive jaundice. METHODS: Based on the level of bilirubin elevation before biliary drainage, patients were stratified into mild jaundice group (bilirubin <250 μmol/L) and severe jaundice group (bilirubin ≥250 μmol/L). Perioperative and prognostic outcomes were compared between the two groups. Categorical data were analyzed using the Chi-squared test, and continuous data that followed a normal distribution were analyzed using independent sample t-tests. Non-normally distributed data were analyzed using the Mann-Whitney U test. Survival analyses of overall survival (OS) and progression-free survival (PFS) was performed using the GraphPad Prism 9 software. P≤0.05 was considered statistically significant. RESULTS: A total of 78 patients (55%) were included in the mild jaundice group and 63 patients (45%) in the severe jaundice group. There was a significant difference in the preferred drainage methods (P<0.001). Regarding surgical and postoperative complications, the proportion of vascular invasion was significantly higher in the severe jaundice group (50.8%) than in the mild jaundice group (33.3%) (P=0.04). However, no impact of vascular invasion on OS and PFS was found in subsequent studies. The OS rate was higher in the mild jaundice group than in the severe jaundice group (P=0.02), but multivariate Cox proportional hazards regression analysis failed to identify this difference as statistically significant. In contrast, patients with biliary tract or pancreatic tumors had significantly worse PFS than those with intestinal tumors (P=0.02), a finding that was confirmed by multivariate Cox proportional hazards regression analysis (P=0.044). Other indicators showed no significant differences (P>0.05). CONCLUSIONS: Patients with mild jaundice may have a better OS rate than those with severe jaundice; however, additional studies are required to validate this finding. Different preoperative biliary drainage (PBD) methods did not affect patients' short- or long-term outcomes, biliary tract and pancreatic tumors may be associated with more rapid relapse and progression.