Abstract
OBJECTIVE: High uric acid (UA) facilitates diabetes progression and is responsible for developing other diseases, such as cardiovascular disease and renal disease. Lifestyle modifications could lower UA level, but relevant evidence is required in patients with type 2 diabetes. This study intended to explore the influence of different physical activities and sitting time on UA level in patients with type 2 diabetes. METHODS: Data on UA level, physical performance, and sitting time from 1892 patients with type 2 diabetes were retrospectively obtained from the Third People's Hospital of Datong, a subcenter of the Metabolic Management Center (MMC) Central database. RESULTS: There were 15.8%, 29.7%, 29.5%, and 25.0% of patients with inactive, mild, moderate, and vigorous intensity of physical activity. UA level presented a U-shaped distribution among patients with different intensities of physical activity, with the lowest in patients with mild intensity of physical activity and the highest in patients with vigorous intensity of physical activity (P = 0.007). There were 58.1% and 41.9% of patients with a sitting time of ≤30 h/week and >30 h/week. UA level was lower in patients with sitting time ≤30 h/week than those with sitting time > 30 h/week (P = 0.014). The above findings were confirmed by multivariate linear regression models. CONCLUSIONS: Mild intensity of physical activity and sitting time ≤ 30 h/week are recommended for reducing UA level in patients with type 2 diabetes.