Effect of Surface Coating on the Toxicity of Silver Nanomaterials on Human Skin Keratinocytes

表面涂层对银纳米材料对人体皮肤角质形成细胞毒性的影响

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作者:Wentong Lu, Dulal Senapati, Shuguang Wang, Oleg Tovmachenko, Anant Kumar Singh, Hongtao Yu, Paresh Chandra Ray

Abstract

As nanotechnology field continues to develop, assessing nanoparticle toxicity is very important for advancing nanoparticles for daily life application. In this Letter, we report the effect of surface coating on cyto, geno and photo-toxicity of silver nanomaterials of different shapes on human skin HaCaT keratinocytes. We found that the citrate coated colloidal silver nanoparticles at 100 µg/mL level are not geno-, cyto- and phtotoxic. On the other hand, citrate coated powder form of the silver nanoparticles are toxic. We have demonstrated that coating of the silver nanoparticles with a biodegradable polymer prevents the toxicity of the powder. Toxicity mechanism has been discussed.

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