Abstract
INTRODUCTION: Laboratory safety behavior is crucial for minimizing risks in high-hazard clinical settings, yet behavioral non-compliance persists as a leading cause of laboratory accidents despite established protocols. METHODS: This study evaluated safety behavior among 92 personnel employed in genetic diagnostic laboratories in Istanbul using a validated 34-item safety behavior scale. Principal component analysis (PCA), multiple linear regression, and k-nearest neighbors (k-NN) classification were employed to analyze the data. RESULTS: The analysis revealed three underlying behavioral dimensions: personal compliance, proactive behavior, and institutional engagement. Regression analysis indicated that perceived institutional support and the frequency of safety training were significant predictors of overall safety behavior (R (2) = 0.47, p < 0.001). Furthermore, the k-NN classifier utilizing PCA-derived components achieved an 88% accuracy rate in distinguishing high and low compliance profiles. DISCUSSION: These findings underscore the utility of multivariate behavioral analytics in profiling laboratory safety behavior and highlight the potential of data-informed, classification-based strategies to enhance safety interventions. Adopting behaviorally tailored approaches to training and institutional support may markedly improve compliance and mitigate risk in laboratory environments.