Abstract
OBJECTIVE: Maternal moderate-intensity exercise during pregnancy has important health benefits for the offspring, however, less is known about its association with offspring attention-deficit/hyperactivity disorder (ADHD). This study aimed to explore the association between maternal exercise during pregnancy and ADHD among preschool children in Southwest China. METHODS: A web-based cross-sectional study was performed in 2021, and the revised Conners Parental Symptom Questionnaire and maternal exercise during pregnancy were obtained through a self-reported structured questionnaire. A binary logistic regression model was used to assess the association between maternal exercise during pregnancy and the likelihood of childhood ADHD after adjustment for covariates. RESULTS: A total of 4,184 preschool children aged 3-6 years were included in our final analysis. Children whose mothers exercised for <20 min per day were more likely to be at risk of ADHD (6.3%), compared to those whose mothers exercised for more than 40 min (3.1%) or 20-40 min (2.8%) per day. Daily exercise of <20 min during pregnancy was associated with higher odds of childhood ADHD (adjusted OR = 2.11; 95% CI: 1.41, 3.16) after multivariable adjustment. The association of maternal exercise during pregnancy with childhood ADHD was similar in subgroups stratified by child's sex, and by maternal smoking, sleep duration and gestational anemia during pregnancy. CONCLUSION: Our findings highlight the importance of maternal moderate-intensity exercise during pregnancy for the prevention of childhood ADHD. Prospective studies are needed to confirm our findings in the future.