Tuning the Antigen Density Requirement for CAR T-cell Activity

调整 CAR-T 细胞活性的抗原密度要求

阅读：9

作者：Robbie G Majzner, Skyler P Rietberg, Elena Sotillo, Rui Dong, Vipul T Vachharajani, Louai Labanieh, June H Myklebust, Meena Kadapakkam, Evan W Weber, Aidan M Tousley, Rebecca M Richards, Sabine Heitzeneder, Sang M Nguyen, Volker Wiebking, Johanna Theruvath, Rachel C Lynn, Peng Xu, Alexander R Dunn,

期刊：

Cancer Discovery

影响因子：

29.700

时间：

2020

起止号：

2020 May;10(5):702-723.

doi：

10.1158/2159-8290.CD-19-0945

研究方向：

细胞生物学

细胞类型：

T细胞

Significance

Optimal CAR T-cell activity is dependent on antigen density, which is variable in many cancers, including lymphoma and solid tumors. CD28ζ-CARs outperform 4-1BBζ-CARs when antigen density is low. However, 4-1BBζ-CARs can be reengineered to enhance activity against low-antigen-density tumors while maintaining their unique capacity for persistence.This article is highlighted in the In This Issue feature, p. 627.

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