Abstract
AIM: Pancreatoduodenectomy (PD) is a highly invasive surgical procedure associated with postoperative malnutrition. Laparoscopic pancreatoduodenectomy (LPD) is a minimally invasive alternative, but its long-term effects on nutritional outcomes remain unclear. This study aimed to compare long-term nutritional outcomes between LPD and open PD (OPD) and to identify factors influencing postoperative nutritional status. METHODS: A retrospective analysis was conducted on 65 patients who underwent PD. Nutritional indicators, including the psoas muscle index (PMI), prognostic nutritional index, and liver-to-spleen ratio, were assessed at 3, 6, and 12 months postoperatively. Multivariate analysis was performed to determine factors affecting nutritional outcomes. RESULTS: The LPD group (n = 36) demonstrated better PMI preservation at 12 months compared with the OPD group (n = 29) (p = 0.002), with significantly lower fatty liver incidence (3.7% vs. 22.7%, p = 0.038) and higher prognostic nutritional index values at 3 months (p = 0.029). LPD was identified as an independent factor for improved PMI (p = 0.020). Additionally, LPD was associated with reduced blood loss and shorter hospital stays. CONCLUSION: LPD improves long-term nutritional outcomes by preserving muscle mass and reducing metabolic disruptions, thus supporting its role in enhancing postoperative recovery and quality of life. Further prospective studies are warranted to confirm these findings.