A PDE-regularized smoothing method for space-time data over manifolds with application to medical data

一种用于流形上时空数据的偏微分方程正则化平滑方法及其在医学数据中的应用

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Abstract

We propose an innovative statistical-numerical method to model spatio-temporal data, observed over a generic two-dimensional Riemanian manifold. The proposed approach consists of a regression model completed with a regularizing term based on the heat equation. The model is discretized through a finite element scheme set on the manifold, and solved by resorting to a fixed point-based iterative algorithm. This choice leads to a procedure which is highly efficient when compared with a monolithic approach, and which allows us to deal with massive datasets. After a preliminary assessment on simulation study cases, we investigate the performance of the new estimation tool in practical contexts, by dealing with neuroimaging and hemodynamic data.

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