Abstract
The feedforward/feedback classification, as originally stated in relation to early visual areas in the macaque monkey, has had a significant influence on ideas of laminar interactions, area reciprocity, and cortical hierarchical organization. In some contrast with this macroscale "laminar connectomics," a more cellular approach to cortical connections, as briefly surveyed here, points to a still underappreciated heterogeneity of neuronal subtypes and complex microcircuitries. From the perspective of heterogeneities, the question of how brain regions interact and influence each other quickly leads to discussions about concurrent hierarchical and nonhierarchical cortical features, brain organization as a multiscale system forming nested groups and hierarchies, connectomes annotated by multiple biological attributes, and interleaved and overlapping scales of organization.