Genomic organization of a Gamma-6 papillomavirus metagenomic discovered from vaginal swab samples of Chinese pregnant women

从中国孕妇阴道拭子样本中发现的 Gamma-6 乳头瘤病毒宏基因组的基因组组织

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作者:Yu Ling, Jianqiang Wang, Jun Yin, Jianpu Xu, Yufan Wu, Rui Zhou, Juan Lu, Shixing Yang, Xiaochun Wang, Quan Shen, Wen Zhang

Abstract

A complete genome sequence of human papillomaviruses (HPV) named as HPV-ujs-21015 was determined by viral metagenomic and PCR methods. The complete genome is 7354 bp in length with GC content of 41.7%, of which the genome was predicted to contain six ORFs (Open Reading Frame, ORF) coding for four early proteins (E7, E1, E4, and E2) and two late proteins (L1 and L2). Phylogenetic analysis based on the complete genome and the L1 protein showed that HPV-ujs-21015 belongs to a type 214 member within genus Gamma-6 papillomavirus. It is the first complete genome of Gamma-6 papillomavirus discovered from pregnant women in China.

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