Abstract
Asthma is one of the most prevalent chronic disorders in children. Anti-inflammatory reliever (AIR) therapy and single maintenance and reliever therapy (SMART) have been adopted into the asthma management of adolescents and adults. However, limited evidence and guidance are currently available for asthma management of younger children with AIR therapy and SMART. Despite the potential benefits of these therapies, the evidence supporting their safety and efficacy in early childhood is evolving. Our review summarizes the current evidence regarding the risks and benefits of AIR therapy and SMART. Moreover, we also identified commonly known challenges of adopting AIR therapy and SMART for younger children as well as proposed potential solutions. Our review aims to offer a foundation for future research and clinical guidance to serve younger patients who could benefit from AIR therapy and SMART. This insight could ultimately lead to safer, more effective, and widely accessible asthma management options for children.