Abstract
Our study provides a detailed exploration of the role of tryptophan metabolism in pancreatic cancer, including its normal function, the impact of targeted drugs, and the influence of gut microbiota on metabolism. Additionally, the article discusses how tryptophan metabolism affects early diagnosis, immune microenvironment, metastasis and proliferation, and pharmaceutical interventions in pancreatic cancer. Research has found that tryptophan and its metabolites can serve as potential biomarkers for early diagnosis and may improve the prognosis of pancreatic cancer patients by modulating the tumor immune microenvironment.