Abstract
This study investigates the effects of fucoidan extracted from Sargassum angustifolium on coagulation factors and biochemical parameters in male Wistar rats. Fucoidan, a sulfated polysaccharide from brown algae, is known for its anticoagulant, anti-cancer, and antioxidant properties METHODS: The study involved 25 rats, divided into control, sham, and three experimental groups, receiving varying doses of fucoidan (100, 150, and 200 mg/kg body weight) over 28 days. The research focused on Prothrombin Time, Thrombin Time, and Partial Thromboplastin Time, along with biochemical markers like glucose, total protein, iron-related parameters, and albumin RESULTS: This study found that fucoidan administration did not significantly affect the hemostasis tests, suggesting minimal impact on coagulation pathways in vivo. However, a dose-dependent reduction in glucose levels was observed, highlighting the potential of fucoidan as a hypoglycemic agent. Additionally, significant increases in transferrin, iron, and ferritin levels were noted, implying enhanced iron absorption and storage CONCLUSION: The findings underscore the therapeutic potential of fucoidan, particularly in managing glucose metabolism and iron homeostasis, while its minimal anticoagulant effect suggests safe usage in clinical settings where anticoagulation is undesirable. Further research is recommended to explore the full clinical benefits of fucoidan.