STIM1 deficiency is linked to Alzheimer's disease and triggers cell death in SH-SY5Y cells by upregulation of L-type voltage-operated Ca2+ entry
STIM1 缺乏与阿尔茨海默病有关，并通过上调 L 型电压操作 Ca2+ 进入来引发 SH-SY5Y 细胞死亡
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作者：Carlos Pascual-Caro, Maria Berrocal, Aida M Lopez-Guerrero, Alberto Alvarez-Barrientos, Eulalia Pozo-Guisado, Carlos Gutierrez-Merino, Ana M Mata, Francisco Javier Martin-Romero
Key messages
STIM1 protein expression decreases with the progression of neurodegeneration in Alzheimer's disease. STIM1 is essential for cell viability in differentiated SH-SY5Y cells. STIM1 deficiency triggers voltage-regulated Ca2+ entry-dependent cell death. Mitochondrial dysfunction and senescence are features of STIM1-deficient differentiated cells.
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