Abstract
The selective oxidation of alcohol-d (1) to prepare aldehyde-d (1) was newly developed by means of NaBD(4) reduction/activated MnO(2) oxidation. Various aldehyde-d (1) derivatives including aromatic and unsaturated aldehyde-d (1) can be prepared with a high deuterium incorporation ratio (up to 98% D). Halogens (chloride, bromide, and iodide), alkene, alkyne, ester, nitro, and cyano groups in the substrates are tolerated under the mild conditions.