Case of type 2 diabetes possibly caused by excessive accumulation of visceral fat in a child born small-for-gestational age

一例2型糖尿病病例,可能由出生时小于胎龄的儿童体内内脏脂肪过度堆积引起。

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Abstract

We encountered a 12-year-old boy with type 2 diabetes who was born small-for-gestational age. We described his clinical characteristics and a possible etiological factor for development of hyperglycemia. He developed well with sufficient nutrition and progressed to being overweight at 6 years-of-age as a result of a high-calorie, high-protein intake diet. He showed a diabetic pattern with a normal insulin response on an oral glucose tolerance test carried out with the urine glucose screening program at schools. He showed a large total fat area of 239.4 cm(2) ; in particular, his visceral fat area was 103.0 cm(2) with a high ratio of visceral fat area to subcutaneous fat area (0.76). The present case might show that insulin resistance, possibly as a result of accumulation of a great amount of visceral fat, might be attributed to the pathogenesis of type 2 diabetes in children born small-for-gestational age.

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