Abstract
BACKGROUND: Functional foods have been widely used as the anti-diabetic agents worldwide. Existing studies presented conflicting results of anti-hyperglycemic properties of gums. This systematic review and meta-analysis study evaluated the existing trials and determined the efficacy of different gums on glycemic indices. METHOD: Systematic search was performed on four main databases (PubMed, Scopus, Embase, Web of Science) by November 2023 using medical subject headings. The meta-analyses were conducted on the findings of the studies of guar gum supplementation on glycemic indices including fasting blood glucose (FBG) and HbA1c (hemoglobinA1c) and systematic review studies include the effect of xanthan gum, arabic gum, bitter almond gum, flaxseed gum, oat gum, gellan gum, locust been gum, tragacanth gum, and karaya gum on fasting plasma insulin, postprandial plasma glucose, HbA1c and Homeostatic Model Assessment for Insulin Resistance (HOMA - IR). RESULTS: Totally, 42 studies were included in this systematic review. Regarding guar gum, xanthan gum, and Arabic gum, most of included studies in our investigation showed that guar gum can be considered as an anti-hyperglycemic agent. Results on other types of gums including bitter almond gum, flaxseed gum, oat gum, gellan gum, locust been gum, tragacanth gum, and karaya gum are limited and exact interpretation cannot be obtained. In meta-analysis on 17 studies of guar gum, it was identified guar gum had a non-significant decrease of 3.02 mg/dl (Mean difference: -3.02, CI 95%: -7.60, 1.56) on the fasting glucose and 0.23 (Mean difference: -0.23, CI 95%: -0.63, 0.17) on HbA1c. CONCLUSION: Modification of food processing using gums may be a promising strategy to help modulate glycemic indices. More studies with larger sample size are needed, both with acute and long-term interventions to clarify this issue. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40200-024-01541-0.