Abstract
Clinical 'single station N2' is a prognostic factor, which is only moderately identifiable preoperatively, even after adequate mediastinal staging. There is little evidence that 'single station N2' predicts for the outcome of any radical treatment strategy, or for a benefit of postoperative radiotherapy. In adequately staged patients with clinical 'single station N2' involvement, modern definitive chemoradiation therapy results in equivalent outcome as induction therapy followed by resection.