Abstract
BACKGROUND: Organ segmentation is an important step in computer-aided diagnosis and pathology detection. Accurate kidney segmentation in abdominal computed tomography (CT) sequences is an essential and crucial task for surgical planning and navigation in kidney tumor ablation. However, kidney segmentation in CT is a substantially challenging work because the intensity values of kidney parenchyma are similar to those of adjacent structures. RESULTS: In this paper, a coarse-to-fine method was applied to segment kidney from CT images, which consists two stages including rough segmentation and refined segmentation. The rough segmentation is based on a kernel fuzzy C-means algorithm with spatial information (SKFCM) algorithm and the refined segmentation is implemented with improved GrowCut (IGC) algorithm. The SKFCM algorithm introduces a kernel function and spatial constraint into fuzzy c-means clustering (FCM) algorithm. The IGC algorithm makes good use of the continuity of CT sequences in space which can automatically generate the seed labels and improve the efficiency of segmentation. The experimental results performed on the whole dataset of abdominal CT images have shown that the proposed method is accurate and efficient. The method provides a sensitivity of 95.46% with specificity of 99.82% and performs better than other related methods. CONCLUSIONS: Our method achieves high accuracy in kidney segmentation and considerably reduces the time and labor required for contour delineation. In addition, the method can be expanded to 3D segmentation directly without modification.