Significance
Remarkable underwater adhesion strategy employed by mussels has been utilized to design a wide variety of biomaterials ranging from tissue adhesives to drug carrier and tissue engineering scaffolds. Catechol is the main adhesive moiety that is widely incorporated to create an injectable biomaterials and bioadhesives. However, the biocompatibility and biological responses associated with the byproducts generated during the curing process of catechol has never been characterized. In this manuscript, we design a model system to systemically characterize the release of hydrogen peroxide (H2O2) during the crosslinking of catechol. Given the multitude of biological responses associated with H2O2 (i.e., wound healing, antimicrobial, chronic inflammation), its release from catechol-containing biomaterials need to be carefully monitored and controlled for a desired application.
Statement of significance
Remarkable underwater adhesion strategy employed by mussels has been utilized to design a wide variety of biomaterials ranging from tissue adhesives to drug carrier and tissue engineering scaffolds. Catechol is the main adhesive moiety that is widely incorporated to create an injectable biomaterials and bioadhesives. However, the biocompatibility and biological responses associated with the byproducts generated during the curing process of catechol has never been characterized. In this manuscript, we design a model system to systemically characterize the release of hydrogen peroxide (H2O2) during the crosslinking of catechol. Given the multitude of biological responses associated with H2O2 (i.e., wound healing, antimicrobial, chronic inflammation), its release from catechol-containing biomaterials need to be carefully monitored and controlled for a desired application.