Abstract
BACKGROUND: Neurological dysfunction is an important consequence of hypothyroidism. Some of the neurologic manifestations of hypothyroidism include somnolence, lethargy, impaired memory and concentration, depression and entrapment neuropathy. Rarer but reversible neurological manifestations include cerebellar ataxia, psychosis, dementia and myxedema coma. PURPOSE: The aim of the present study was to evaluate the usefulness of the blink reflex as a method for obtaining an early diagnosis of central nervous system dysfunction in hypothyroid patients who do not have signs or symptoms of nervous system dysfunction. METHODS: Forty-eight patients with mean age 40 (± 11), with newly diagnosed primary hypothyroidism and 20 healthy control subjects were included in the study. The patients were divided into subclinical and overt hypothyroidism. Patients with normal T3/T4 with elevated TSH were considered subclinical hypothyroids. For blink reflex testing, subjects lay supine on a bed in a warm room with eyes gently closed. Recordings were performed with an EMG machine (Nihon Kohdeni'Neuropack), with a filter setting of 20 Hz to 10 kHz, using an analysis time of 50 ms. Recordings were performed with surface recording electrodes (Dantec 13K60, Copenhagen, Denmark). RESULTS: Second ipsilateral response (R2I) and second contralateral response (R2C) latencies in hypothyroidism were prolonged relative to controls, and the differences were statistically significant (P<0.001 and P<0.001, respectively). Latency of Rl, R2I, and R2C did not correlate linearly free T3, free T4, or TSH values in the hypothyroid group. CONCLUSION: The finding of abnormal blink reflex responses in hypothyroid individuals raises the notion that they may be useful in detecting early changes and in the follow-up of the patients with the disorder.