Recombinant human interferon-α1b inhibits SARS-CoV-2 better than interferon-α2b in vitro

重组人干扰素-α1b 在体外抑制 SARS-CoV-2 的效果优于干扰素-α2b

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作者:Danrong Shi, Keda Chen, Xiangyun Lu, Linfang Cheng, Tianhao Weng, Fumin Liu, Nanping Wu, Lanjuan Li, Hangping Yao

Abstract

•A comprehensive evaluation method for anti-SARS-CoV-2 drugs was established based on qPCR, TCID50, and immunofluorescence.•A significant antiviral effect of rHuIFN-α1b was shown in Vero and Calu-3 ​cells.•rHuIFN-α1b has a good potential in the application of anti-COVID-19 therapy.

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