Abstract
BACKGROUND: Although the associations between common single nucleotide polymorphisms (SNPs) of EFEMP1 gene and glioma risk have been investigated in Chinese population-based case-control studies, investigation results for several SNPs are inconsistent. In addition, the single-center study has a poor statistical power due to finite sample size. Therefore, a meta-analysis was conducted to comprehensively determine the associations. METHODS: All eligible case-control studies were obtained by searching PubMed, EMBASE, Web of Science, and Chinese National Knowledge Infrastructure. Pooled odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of the associations in fixed- or random-effects model. RESULTS: EFEMP1 rs1346787 polymorphism was significantly associated with glioma risk in Chinese population under all genetic models (GG vs AA, OR =2.22, 95% CI =1.46-3.36; AG vs AA, OR =1.54, 95% CI =1.27-1.87; (GG+AG) vs AA, OR =1.60, 95% CI =1.34-1.93; GG vs (AG+AA), OR =1.86, 95% CI =1.24-2.78; G vs A, OR =1.54, 95% CI =1.32-1.79). However, the significant association of EFEMP1 rs1346786 with glioma risk in Chinese population was observed only under heterozygous model of AG vs AA (OR =1.34, 95% CI =1.10-1.62), dominant model of (GG+AG) vs AA (OR =1.36, 95% CI =1.13-1.63), and allelic model of G vs A (OR =1.28, 95% CI =1.10-1.50). CONCLUSION: Our study demonstrated that EFEMP1 polymorphisms, especially rs1346787 and rs1346786, might predict glioma risk in Chinese population. However, high-quality case-control studies with larger sample sizes are warranted to confirm the above-mentioned findings.