Feasibility of a lateral flow test for neurocysticercosis using novel up-converting nanomaterials and a lightweight strip analyzer

使用新型上转换纳米材料和轻型试纸分析仪进行脑囊尾蚴病横向流动检测的可行性

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作者:Paul L A M Corstjens, Claudia J de Dood, Jeffrey W Priest, Hans J Tanke, Sukwan Handali; Cysticercosis Working Group in Peru

Conclusion

Proof-of-principle, of a rapid UCP-LF screening assay for neurocysticercosis was demonstrated. The assay utilized bacterial-expressed rT24H as a potential alternative for baculovirus-expressed rT24H. Performance of the UCP-LF assay was excellent, although further studies need to confirm that bacterial expressed antigen can entirely replace previously used baculovirus antigen. In addition, the increasing availability of commercial sources for UCP reporter materials as well as the accessibility of affordable semi-handheld scanners may allow UCP-based bioanalytical systems for point-of-care to evolve at an even faster pace.

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