Abstract
Peutz-Jeghers Syndrome (PJS) is a rare autosomal dominant disorder marked by mucocutaneous pigmentation and gastrointestinal hamartomatous polyps, with a predisposition to malignancy. We present a 48-year-old male with known PJS who arrived at the emergency department with right flank abdominal pain. CT imaging revealed multiple small bowel intussusceptions-most notably in the right flank-alongside hyperdense intraluminal polyps. The patient underwent exploratory laparotomy, where manual reduction of the intussusceptions and surgical resection of polyps were performed. Postoperative recovery was uneventful, and he was enrolled in a surveillance program. We present the case of a 48-year-old male with Peutz-Jeghers Syndrome who developed multiple small bowel intussusceptions. This case highlights the importance of cross-sectional imaging, particularly CT and MRI enterography, in diagnosing complications and guiding treatment in adult PJS. Long-term management involves routine imaging, polyp surveillance, and cancer screening.