Abstract
COVID-19-related encephalopathy is a complication of COVID-19 that affects the brain. It can present with symptoms such as altered mental status, ranging from mild confusion to deep coma. It is a major and devastating complication of the SARS-CoV-2 virus. COVID-19-related neurological symptoms may be associated with cytokine release induced by the virus, and tocilizumab targeting IL-6 receptor may provide significant benefits. We report a case of COVID-19-related encephalopathy with cerebrospinal fluid analysis revealing significantly elevated levels of IL-6. Brain magnetic resonance imaging showed a bilateral high signal in the claustrum, and treatment with tocilizumab was effective.