Abstract
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the effect of the number of PEG‐asparaginase doses on survival and relapse in children and adolescents with acute lymphoblastic leukaemia (ALL). SECONDARY OBJECTIVES: To assess the association between the number of doses of PEG‐asparaginase and asparaginase‐associated toxicities (e.g. hypersensitivity, thromboembolism, pancreatitis and osteonecrosis). To undertake a network meta‐analysis (NMA) at dose‐level in order to generate rankings of the number of doses of PEG‐asparaginase used in the treatment for ALL, according to their benefits (survival and relapse) and harms (toxicity).