Conclusions
The increased concentrations of examined parameters indicate enhanced cell damage, inflammation and aggravation of proteolytic processes in CKD children. Variability in behavior of selected markers and existing correlations point at the complexity of relations between different elements responsible for the fibrosis puzzle.
Methods
80 children with CKD stages 1-5 and 30 controls were enrolled in the study. Serum concentrations of examined parameters were assessed by ELISA.
Results
Median values of all markers were significantly elevated in CKD patients vs. controls. sE-selectin and MMP-2 concentrations kept growing from the beginning of renal failure progression. TIMP-1, TIMP-2 and TGFβ1 levels remained unchanged in the late CKD stages, whereas Hsp90α concentrations decreased significantly in CKD stage 5. All parameters, except for MMP-2, correlated with TGFβ1, but the strongest predictive value was seen in the case of TIMP-1 and TIMP-2. Conclusions: The increased concentrations of examined parameters indicate enhanced cell damage, inflammation and aggravation of proteolytic processes in CKD children. Variability in behavior of selected markers and existing correlations point at the complexity of relations between different elements responsible for the fibrosis puzzle.