Abstract
PURPOSE: The impact of SARS-CoV-2 infection on pre-existing retinal pathology is currently unknown. OBSERVATIONS: We present a unique case of rapidly progressing diabetic retinopathy (DR) following severe COVID-19 infection requiring supplemental oxygen and subsequent long-COVID. CONCLUSIONS AND IMPORTANCE: Following infection with SARS-CoV-2, the associated acute and possible long-term hypoxia has the potential to affect the retina and accelerate the natural course of diabetic retinopathy.