Significance
By combining quantitative proteomics, bioinformatics and WB/IHC analysis, this study reports the results of the first comparative study on proteome-wide changes in the olfactory bulb under different levels of olfactory input. Odor deprivation and stimulation induced proteomic changes clearly demonstrate significant metabolic shifts and alterations on synaptic transmission. This quantitative system biology study leads to a new level of understanding in the development of olfactory bulb plasticity induced by odor deprivation or stimulation, and provides many new clues for the olfactory bulb related functional studies.