Abstract
RATIONALE: Intussusception secondary to sigmoid colon lipoma is a rare cause of adult intestinal obstruction. Due to its low prevalence and nonspecific clinical features, diagnosis is often delayed. Early recognition is critical to prevent disease complications and improve patient outcomes. PATIENT CONCERNS: We reported a 71-year-old female patient who presented with severe abdominal pain and bloody stool. DIAGNOSES: The abdominal computed tomography scan, colonoscopy, and pathological examination indicated that it was a lipoma. INTERVENTIONS: The patient underwent sigmoid colectomy with end-to-end coloanal anastomosis. OUTCOMES: The patient experienced an uneventful postoperative recovery. LESSONS: In adults, especially the elderly, intussusception secondary to lipoma is rare, and diagnosis is often complicated by intermittent symptoms. Multimodal evaluation (computed tomography, colonoscopy, and histopathology) is essential for diagnostic accuracy. Timely surgical intervention alleviates intestinal obstruction while establishing a definitive diagnosis, necessitating heightened clinical vigilance for this rare entity.