Genotype 5 Hepatitis E Virus Produced by a Reverse Genetics System Has the Potential for Zoonotic Infection

通过反向遗传系统产生的基因型 5 型戊型肝炎病毒具有人畜共患感染的潜力

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作者:Tian-Cheng Li, Huimin Bai, Sayaka Yoshizaki, Yasushi Ami, Yuriko Suzaki, Yen Hai Doan, Kazuaki Takahashi, Shunji Mishiro, Naokazu Takeda, Takaji Wakita

Conclusion

Infectious G5 HEV was produced using a reverse genetics system, and the antigenicity was identical to that of human HEVs and G7 HEV. Transmission of G5 HEV to primates was confirmed by an experimental infection, providing evidence of the possibility of zoonotic infection by G5 HEV.

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