A new type of toxin A-negative, toxin B-positive Clostridium difficile strain lacking a complete tcdA gene

一种新型的毒素A阴性、毒素B阳性的艰难梭菌菌株,缺乏完整的tcdA基因。

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Abstract

Toxins A and B are the main virulence factors of Clostridium difficile and are the targets for molecular diagnostic tests. Here, we describe a new toxin A-negative, toxin B-positive, binary toxin CDT (Clostridium difficile transferase)-negative (A(-) B(+) CDT(-)) toxinotype (XXXII) characterized by a variant type of pathogenicity locus (PaLoc) without tcdA and with atypical organization of the PaLoc integration site.

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