Estrone-3-Sulfate Stimulates the Proliferation of T47D Breast Cancer Cells Stably Transfected With the Sodium-Dependent Organic Anion Transporter SOAT (SLC10A6)
雌酮-3-硫酸盐刺激稳定转染钠依赖性有机阴离子转运体 SOAT (SLC10A6) 的 T47D 乳腺癌细胞增殖
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作者：Emre Karakus, Daniel Zahner, Gary Grosser, Regina Leidolf, Cemal Gundogdu, Alberto Sánchez-Guijo, Stefan A Wudy, Joachim Geyer
Conclusion
The present study clearly demonstrates expression of SOAT in breast cancer tissue with ductal localization. SOAT inhibition can block the E1S-stimulated proliferation of T47D breast cancer cells, demonstrating that SOAT is an interesting novel drug target from the group of E1S uptake carriers for anti-proliferative breast cancer therapy.
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