Abstract
RATIONALE: Pyoderma gangrenosum (PG) is a rare skin disease. Pregnancy is a unique physiological condition. Here we report a rare case of PG after cesarean section. PATIENT CONCERNS: A 32-year-old female presented with wound breakdown 1 day after cesarean section, with progression to a skin ulcer and no response to antibiotic therapy. DIAGNOSES: We experienced a case of PG after cesarean section. This was initially misdiagnosed as a wound infection, with fever and wound redness as clinical manifestations. INTERVENTIONS: The patient was initially treated with antibiotics, followed by glucocorticoid and human immunoglobulin therapy. Wound debridement, vacuum sealing negative pressure drainage, skin grafting, and hyperbaric oxygen therapy were also performed. OUTCOMES: The wound healed without adverse reactions. LESSONS: When a surgical incision infection does not respond to antibiotic treatment and the culture is negative, PG should be considered.