Klotho suppresses high phosphate-induced osteogenic responses in human aortic valve interstitial cells through inhibition of Sox9
Klotho 通过抑制 Sox9 抑制人类主动脉瓣间质细胞中高磷酸盐诱导的成骨反应
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作者：Fei Li, Qingzhou Yao, Lihua Ao, Joseph C Cleveland Jr, Nianguo Dong, David A Fullerton, Xianzhong Meng
Key messages
CAVD associated with chronic kidney disease is a significant clinical problem. High phosphate upregulates Sox9 through AKT and PKD in human AVICs. Calcified human aortic valves have lower levels of Klotho. Klotho suppresses Sox9 upregulation and intranuclear translocation. Klotho inhibits high phosphate-induced osteogenic activity in human AVICs.
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