Aims
The mechanism by which SR48692 inhibits non-small cell lung cancer (NSCLC) proliferation was investigated. Main
Methods
The ability of SR48692 to inhibit the proliferation of NSCLC cell lines NCI-H1299 and A549 was investigated in vitro in the presence or absence of neurotensin (NTS). The ability of NTS to cause epidermal growth factor receptor (EGFR) transactivation was investigated by Western blot using NSCLC cells and various inhibitors. The growth effects and Western blot
Significance
These results suggest that SR48692 may inhibit NSCLC proliferation in an EGFR-dependent mechanism.