Interleukin-1-induced changes in the glioblastoma secretome suggest its role in tumor progression

白细胞介素-1诱导的胶质母细胞瘤分泌组变化表明其在肿瘤进展中的作用

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作者:Leonid Tarassishin #, Jihyeon Lim #, D Brent Weatherly, Ruth H Angeletti, Sunhee C Lee

Significance

Present study is on an unbiased screening of the glioblastoma secretome stimulated by IL-1 which triggers neuroinflammatory cascades in the central nervous system. Network of secreted proteins were shown to be regulated revealing their possible contribution to glioma progression. Label free quantitative proteomics has provided unique novel targets for potential glioblastoma intervention.

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