Abstract
To date, the response to coronavirus disease (COVID-19) in many African countries has been quick, forward-looking and adjustable in spite of the continent's limited resources. These responses were triggered by the continuous increase in cases and deaths, which have necessitated speedy development of an effective vaccine. It is anticipated that African governments and public health officials will show more transparency, and provide evidence-based strategies to support COVID-19 vaccines and design equitable as well as effective vaccine delivery plans for the populace. To this end, this review analysed Africa's preparedness and response towards COVID-19 vaccines, potential demand, acceptability and distribution challenges related to the management of the virus. The review takes stock of context-specific vaccine preparedness; the demand for vaccine and associated challenges; as well as vaccine accessibility and its distribution. The review offers insightful approaches and strategies by which African countries can maximize benefits from the COVID-19 vaccines to overcome the virus. These include the pursuance of vaccines that may help confer immunity or protection against the virus in the light of contextual circumstances of specific African countries, including sociocultural and economic issues among other factors.