Abstract
N(6)-methyladenosine (m(6)A) is the most abundant epitranscriptomic mark on mRNA and plays crucial roles in gene expression, cell differentiation, stress responses, and cancer and neurodegenerative diseases. Recent studies have further revealed a new role of m(6)A-modified coding and noncoding RNAs in regulating DNA repair and modulating genome stability. In this review, we first discuss the roles of m(6)A modification in regulating RNA stability and splicing of DNA repair genes, as well as its roles in guiding DNA repair. We then discuss the crosstalk between m(6)A-modified RNA and DNA damage and repair, highlighting several outstanding questions.