Abstract
Inflammatory bowel diseases (IBD) result from genetic and environmental factors. The two clinical manifestations of inflammatory bowel disease are ulcerative colitis and Crohn's disease (IBD). Numerous studies have demonstrated a link between immune system molecules' single nucleotide polymorphisms (SNPs) and the incidence of IBD. The study aimed to examine the potential impact of the SNPs NOD2 rs2066844 and ATG16L1 rs2241880 in a group sample of Iraqi IBD patients. The AG genotype for rs2241880 was associated with an increased risk for CD (P=0.1) and a negative association with UC, whereas the AA genotype presents less in CD patients and a negative association with UC (P=0.89). For this SNP, the G allele was associated with the risk of CD but not for UC. For the rs2066844, there were no significant differences for NOD2 in both CD and UC, and associations between variation and diseases were not observed.